Selective Endothelin-A Versus Combined Endothelin-A/Endothelin-B Receptor Blockade in Rat Chronic Heart Failure
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منابع مشابه
Selective endothelin-A versus combined endothelin-A/endothelin-B receptor blockade in rat chronic heart failure.
BACKGROUND The relative efficacy of endothelin-A (ET(A)) receptor blockade versus combined ET(A)-ET(B) receptor blockade in chronic heart failure (CHF) is still largely unknown. METHODS AND RESULTS We compared, in a rat model of CHF (coronary ligation), the hemodynamic and structural effects of 1 month of treatment with the ET(A) antagonist ABT-627 (5 mg x kg(-1) x d(-1)), the ET(B) antagonis...
متن کاملEndothelin-A/Endothelin-B Receptor Blockade in Rat Chronic Heart Failure
Paul Mulder, Houssaine Boujedaini, Vincent Richard, Genevieve Derumeaux, Jean Paul Henry, in Rat Chronic Heart Failure Selective Endothelin-A Versus Combined Endothelin-A/Endothelin-B Receptor Blockade Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas...
متن کاملDirect comparison of selective endothelin A and non-selective endothelin A/B receptor blockade in chronic heart failure.
OBJECTIVE To investigate the potential differential effects of selective endothelin (ET) A and dual ET-A/B receptor blockade in patients with chronic heart failure. METHODS Nine patients with chronic heart failure (New York Heart Association class II-III) each received intravenous infusions of BQ-123 alone (selective ET-A blockade) and combined BQ-123 and BQ-788 (dual ET-A/B blockade) in a ra...
متن کاملEndothelin receptor blockade in congestive heart failure.
Heart Failure To the Editor: Of the many new therapeutic agents for slowing the progression of congestive heart failure (CHF), other than antagonizing the renin-angiotensin-aldosterone system, blocking the endothelin receptors seems to be most promising. The two latest reports published in Circulation1,2 render further support to this exciting concept. Endothelin may contribute to the symptoms ...
متن کاملAcute endothelin A receptor blockade causes selective pulmonary vasodilation in patients with chronic heart failure.
BACKGROUND Elevated plasma endothelin-1 (ET-1) levels in patients with chronic heart failure correlate with pulmonary artery pressures and pulmonary vascular resistance. ET(A) receptors on vascular smooth muscle cells mediate pulmonary vascular contraction and hypertrophy. We determined the acute hemodynamic effects of sitaxsentan, a selective ET(A) receptor antagonist, in patients with chronic...
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ژورنال
عنوان ژورنال: Circulation
سال: 2000
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.102.5.491